豊中市・阪急岡町駅近くの内科・消化器内科・リハビリテーション科　野田げんきクリニック

主要業績

大阪大学医学部（大阪大学医学研究科）第一内科・消化器内科教授・教官、生化学分子生物学講座教授・教官、消化器外科教授・教官、大阪労災病院消化器内科部長・消化器外科部長・両医局員の皆様、（株）京都科学の皆様には、研究の遂行・とりまとめに際し、多大なるご指導ご鞭撻を賜り、ここに深謝申し上げます。

I)主要英文論文

＜臨床研究＞

A novel physical colonoscopy simulator based on analysis of data from computed tomography colonography.
Noda K*1, Kitada T*2, Suzuki Y*3, Colvin HS, Hata T, Mizushima T.　 (＊1, ＊2, and ＊3, equally contributed)
Surg Today. 2017 Sep;47(9):1153-1162.

Progression of type C chronic hepatitis to liver cirrhosis and hepatocellular carcinoma-its relationship to alcohol drinking and the age of transfusion.
Noda K, Yoshihara H, Suzuki K, Yamada Y, Kasahara A, Hayashi N, Fusamoto H, Kamada T.
Alcohol Clin Exp Res. 1996 Feb;20(1 Suppl):95A-100A.

Induction of antinuclear antibody after interferon therapy in patients with type-C chronic hepatitis: its relation to the efficacy of therapy.
Noda K, Enomoto N, Arai K, Masuda E, Yamada Y, Suzuki K, Tanaka M, Yoshihara H.
Scand J Gastroenterol. 1996 Jul;31(7):716-22.

＜基礎-臨床研究＞

Relationship between elevated FX expression and increased production of GDP-L-fucose, a common donor substrate for fucosylation in human hepatocellular carcinoma and hepatoma cell lines.
Noda K, Miyoshi E, Gu J, Gao CX, Nakahara S, Kitada T, Honke K, Suzuki K, Yoshihara H, Yoshikawa K, Kawano K, Tonetti M, Kasahara A, Hori M, Hayashi N, Taniguchi N.
Cancer Res. 2003 Oct 1;63(19):6282-9.

Gene expression of alpha1-6 fucosyltransferase in human hepatoma tissues: a possible implication for increased fucosylation of alpha-fetoprotein.
Noda K, Miyoshi E, Uozumi N, Yanagidani S, Ikeda Y, Gao C, Suzuki K, Yoshihara H, Yoshikawa K, Kawano K, Hayashi N, Hori M, Taniguchi N.
Hepatology. 1998 Oct;28(4):944-52. Erratum in: Hepatology 1999 Jan;29(1):301. Yoshikawa M [corrected to Yoshikawa K].

Expression of vascular permeability factor/vascular endothelial growth factor in human hepatocellular carcinoma.
Suzuki K, Hayashi N, Miyamoto Y, Yamamoto M, Ohkawa K, Ito Y, Sasaki Y, Yamaguchi Y, Nakase H, Noda K, Enomoto N, Arai K, Yamada Y, Yoshihara H, Tujimura T, Kawano K, Yoshikawa K, Kamada T.
Cancer Res. 1996 Jul 1;56(13):3004-9.

＜基礎研究＞

Deficiency of GMDS leads to escape from NK cell-mediated tumor surveillance through modulation of TRAIL signaling.
Moriwaki K, Noda K, Furukawa Y, Ohshima K, Uchiyama A, Nakagawa T, Taniguchi N, Daigo Y, Nakamura Y, Hayashi N, Miyoshi E.
Gastroenterology. 2009 Jul;137(1):188-98, 198.e1-2.

An enzymatic method of analysis for GDP-L-fucose in biological samples, involving high-performance liquid chromatography.
Noda K, Miyoshi E, Nakahara S, Ihara H, Gao CX, Honke K, Yanagidani S, Sasaki Y, Kasahara A, Hori M, Hayashi N, Taniguchi N.
Anal Biochem. 2002 Nov 1;310(1):100-6.

The O-fucosyltransferase O-fut1 is an extracellular component that is essential for the constitutive endocytic trafficking of Notch in Drosophila.
Sasamura T, Ishikawa HO, Sasaki N, Higashi S, Kanai M, Nakao S, Ayukawa T, Aigaki T, Noda K, Miyoshi E, Taniguchi N, Matsuno K.
Development. 2007 Apr;134(7):1347-56.

Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice.
Wang X, Inoue S, Gu J, Miyoshi E, Noda K, Li W, Mizuno-Horikawa Y, Nakano M, Asahi M, Takahashi M, Uozumi N, Ihara S, Lee SH, Ikeda Y, Yamaguchi Y, Aze Y, Tomiyama Y, Fujii J, Suzuki K, Kondo A, Shapiro SD, Lopez-Otin C, Kuwaki T, Okabe M, Honke K, Taniguchi N.
Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15791-6.

Core fucosylation of N-linked glycans in leukocyte adhesion deficiency/congenital disorder of glycosylation IIc fibroblasts.
Sturla L, Fruscione F, Noda K, Miyoshi E, Taniguchi N, Contini P, Tonetti M.
Glycobiology. 2005 Oct;15(10):924-34.

II)産学連携研究

新規大腸コロンモデル（NKS colon model）の開発
野田げんきクリニック　野田勝久＊1、北田クリニック.　北田学利＊2、松島病院　鈴木康元＊3　(＊1, ＊2, and ＊3, equally contributed)、（株）京都科学

III)主たる総説・新聞掲載

野田勝久、三善英知、谷口直之　肝癌におけるフコシル化糖鎖の分子調節機構について―現状とこれから―、p99-10、2005、遺伝子医学MOOK 3、糖鎖と病気、谷口直之　編、（株）メディカルドウ

大阪労災病院消化器内科　野田勝久、吉原治正、鎌田武信　飲酒者におけるC型肝炎ウイルスHVR1の塩基多様性、ｐ235-241、肝臓病学の最前線1997、中外医学社

大腸がん悪化　カギは糖鎖　治療への応用に光、科学欄（全国版）、７月７日、2009年、朝日新聞

IV）賞与

＜主たる研究業績＞

＜臨床研究：Clinical Study＞

A novel physical colonoscopy simulator based on analysis of data from computed tomography colonography.
Noda K, Kitada T, Suzuki Y, Colvin HS, Hata T, Mizushima T.
Surg Today. 2017 Sep;47(9):1153-1162.

Progression of type C chronic hepatitis to liver cirrhosis and hepatocellular carcinoma--its relationship to alcohol drinking and the age of transfusion.
Noda K, Yoshihara H, Suzuki K, Yamada Y, Kasahara A, Hayashi N, Fusamoto H, Kamada T.
Alcohol Clin Exp Res. 1996 Feb;20(1 Suppl):95A-100A.

Induction of antinuclear antibody after interferon therapy in patients with type-C chronic hepatitis: its relation to the efficacy of therapy.
Noda K, Enomoto N, Arai K, Masuda E, Yamada Y, Suzuki K, Tanaka M, Yoshihara H.
Scand J Gastroenterol. 1996 Jul;31(7):716-22.

＜臨床-基礎研究:Transclinical Study＞

Core fucosylation of N-linked glycans in leukocyte adhesion deficiency/congenital disorder of glycosylation IIc fibroblasts.
Sturla L, Fruscione F, Noda K, Miyoshi E, Taniguchi N, Contini P, Tonetti M.
Glycobiology. 2005 Oct;15(10):924-34.

Relationship between elevated FX expression and increased production of GDP-L-fucose, a common donor substrate for fucosylation in human hepatocellular carcinoma and hepatoma cell lines.
Noda K, Miyoshi E, Gu J, Gao CX, Nakahara S, Kitada T, Honke K, Suzuki K, Yoshihara H, Yoshikawa K, Kawano K, Tonetti M, Kasahara A, Hori M, Hayashi N, Taniguchi N.
Cancer Res. 2003 Oct 1;63(19):6282-9.

Expression and prognostic roles of the G1-S modulators in hepatocellular carcinoma: p27 independently predicts the recurrence.
Ito Y, Matsuura N, Sakon M, Miyoshi E, Noda K, Takeda T, Umeshita K, Nagano H, Nakamori S, Dono K, Tsujimoto M, Nakahara M, Nakao K, Taniguchi N, Monden M.
Hepatology. 1999 Jul;30(1):90-9.

Gene expression of alpha1-6 fucosyltransferase in human hepatoma tissues: a possible implication for increased fucosylation of alpha-fetoprotein.
Noda K, Miyoshi E, Uozumi N, Yanagidani S, Ikeda Y, Gao C, Suzuki K, Yoshihara H, Yoshikawa K, Kawano K, Hayashi N, Hori M, Taniguchi N.
Hepatology. 1998 Oct;28(4):944-52. Erratum in: Hepatology 1999 Jan;29(1):301. Yoshikawa M [corrected to Yoshikawa K].

Expression of vascular permeability factor/vascular endothelial growth factor in human hepatocellular carcinoma.
Suzuki K, Hayashi N, Miyamoto Y, Yamamoto M, Ohkawa K, Ito Y, Sasaki Y, Yamaguchi Y, Nakase H, Noda K, Enomoto N, Arai K, Yamada Y, Yoshihara H, Tujimura T, Kawano K, Yoshikawa K, Kamada T.
Cancer Res. 1996 Jul 1;56(13):3004-9.

＜基礎研究：Basic Study＞

Deficiency of GMDS leads to escape from NK cell-mediated tumor surveillance through modulation of TRAIL signaling.
Moriwaki K, Noda K, Furukawa Y, Ohshima K, Uchiyama A, Nakagawa T, Taniguchi N, Daigo Y, Nakamura Y, Hayashi N, Miyoshi E.
Gastroenterology. 2009 Jul;137(1):188-98, 198.e1-2.

The O-fucosyltransferase O-fut1 is an extracellular component that is essential for the constitutive endocytic trafficking of Notch in Drosophila.
Sasamura T, Ishikawa HO, Sasaki N, Higashi S, Kanai M, Nakao S, Ayukawa T, Aigaki T, Noda K, Miyoshi E, Taniguchi N, Matsuno K.
Development. 2007 Apr;134(7):1347-56.

Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice.
Wang X, Inoue S, Gu J, Miyoshi E, Noda K, Li W, Mizuno-Horikawa Y, Nakano M, Asahi M, Takahashi M, Uozumi N, Ihara S, Lee SH, Ikeda Y, Yamaguchi Y, Aze Y, Tomiyama Y, Fujii J, Suzuki K, Kondo A, Shapiro SD, Lopez-Otin C, Kuwaki T, Okabe M, Honke K, Taniguchi N.
Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15791-6.

Involvement of oligosaccharide changes in alpha5beta1 integrin in a cisplatin-resistant human squamous cell carcinoma cell line.
Nakahara S, Miyoshi E, Noda K, Ihara S, Gu J, Honke K, Inohara H, Kubo T, Taniguchi N.　
Mol Cancer Ther. 2003 Nov;2(11):1207-14.

An enzymatic method of analysis for GDP-L-fucose in biological samples, involving high-performance liquid chromatography.
Noda K, Miyoshi E, Nakahara S, Ihara H, Gao CX, Honke K, Yanagidani S, Sasaki Y, Kasahara A, Hori M, Hayashi N, Taniguchi N.
Anal Biochem. 2002 Nov 1;310(1):100-6.

The enzymatic basis for the conversion of nonfucosylated to fucosylated alpha-fetoprotein by acyclic retinoid treatment in human hepatoma cells: activation of alpha1-6 fucosyltransferase.
Noda K, Miyoshi E, Kitada T, Nakahara S, Gao CX, Honke K, Shiratori Y, Moriwaki H, Sasaki Y, Kasahara A, Hori M, Hayashi N, Taniguchi N.
Tumour Biol. 2002 Jul-Aug;23(4):202-11.

The addition of bisecting N-acetylglucosamine residues to E-cadherin down-regulates the tyrosine phosphorylation of beta-catenin.
Kitada T, Miyoshi E, Noda K, Higashiyama S, Ihara H, Matsuura N, Hayashi N, Kawata S, Matsuzawa Y, Taniguchi N.
J Biol Chem. 2001 Jan 5;276(1):475-80.

The alpha1-6-fucosyltransferase gene and its biological significance.
Miyoshi E, Noda K, Yamaguchi Y, Inoue S, Ikeda Y, Wang W, Ko JH, Uozumi N, Li W, Taniguchi N.
Biochim Biophys Acta. 1999 Dec 6;1473(1):9-20. Review.

Regulation of the GnT-V promoter by transcription factor Ets-1 in various cancer cell lines.
Ko JH, Miyoshi E, Noda K, Ekuni A, Kang R, Ikeda Y, Taniguchi N.
J Biol Chem. 1999 Aug 13;274(33):22941-8.

A fluorescent assay method for GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha 1-6fucosyltransferase activity, involving high performance liquid chromatography.
Uozumi N, Teshima T, Yamamoto T, Nishikawa A, Gao YE, Miyoshi E, Gao CX, Noda K, Islam KN, Ihara Y, Fujii S, Shiba T, Taniguchi N.
J Biochem. 1996 Aug;120(2):385-92.

High expression of alpha-1-6 fucosyltransferase during rat hepatocarcinogenesis.
Noda K, Miyoshi E, Uozumi N, Gao CX, Suzuki K, Hayashi N, Hori M, Taniguchi N.
Int J Cancer. 1998 Jan 30;75(3):444-50.

Expression of alpha1-6 fucosyltransferase in rat tissues and human cancer cell lines.
Miyoshi E, Uozumi N, Noda K, Hayashi N, Hori M, Taniguchi N.
Int J Cancer. 1997 Sep 17;72(6):1117-21.